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rosa.jpg (JPEG Image, 490x500 pixels)

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funny-pictures-random-making-of-you.jpg (JPEG Image, 525x424 pixels)

full.jpg (JPEG Image, 550x668 pixels) - Scaled (83%)

full.jpg (JPEG Image, 550x668 pixels) - Scaled (83%)

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6TVaz38Mgfe86y0q5TijqEgGo1_500.png (PNG Image, 400x400 pixels)

Ayrabella's blog - StumbleUpon

Ayrabella's blog - StumbleUpon

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angelina-jolie-by-david-lachapelle.jpg (JPEG Image, 720x523 pixels)

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kotoponedelnik_na_nasnet_28_foto_8.jpg (JPEG Image, 790x593 pixels) - Scaled (93%)

Nintendo Graffiti….

Mario…

Mega Man…

Mario and Bowser…

Wiimote…

Mario in a boot…

Nintendo Graffiti….

Don't Feed the Plants!

Don't Feed the Plants!

Parenting: Memor From a Child to Parents

Memo From
A Child To Parents

1. Don't spoil me. I know quite well that I ought not to have all I ask for. I'm only testing you.

2. Don't be afraid to be firm with me. I prefer it, it makes me feel secure.

3. Don't let me form bad habits. I have to rely on you to detect them in the early stages.

4. Don't make me feel smaller than I am. It only makes me behave stupidly "big".

5. Don't correct me in front of people if you can help it. I'll take much more notice if you talk quietly with me in private.

6. Don't make me feel that my mistakes are sins. It upsets my sense of values.

7. Don't protect me from consequences. I need to learn the painful way sometimes.

8. Don't be too upset when I say "I hate you". Sometimes it isn't you I hate but your power to thwart me.

9. Don't take too much notice of my small ailments. Sometimes they get me the attention I need.

10. Don't nag. If you do, I shall have to protect myself by appearing deaf.

11. Don't forget that I cannot explain myself as well as I should like. That is why I am not always accurate.

12. Don't put me off when I ask questions. If you do, you will find that I stop asking and seek my information elsewhere.

13. Don't be inconsistent. That completely confuses me and makes me lose faith in you.

14. Don't tell me my fears are silly. They are terribly real and you can do much to reassure me if you try to understand.

15. Don't ever suggest that you are perfect or infallible. It gives me too great a shock when I discover that you are neither.

16. Don't ever think that it is beneath your dignity to apologize to me. An honest apology makes me feel surprisingly warm towards you.

17. Don't forget I love experimenting. I couldn't get along without it, so please put up with it.

18. Don't forget how quickly I am growing up. It must be very difficult for you to keep pace with me, but please do try.

19. Don't forget that I don't thrive without lots of love and understanding, but I don't need to tell you, do I?

20. Please keep yourself fit and healthy. I need you.

(Reprinted with permission from The Message International, June 1991, p. 40)

Comments? Criticism? ideas? Talk to us. Let's develop a partnership about parenting by sharing with each other: parenting@soundvision.com

 

Parenting: Memor From a Child to Parents

30_jail_birds_big.gif (GIF Image, 443x443 pixels)

30_jail_birds_big.gif (GIF Image, 443x443 pixels)

Epic FAIL’s from around the world | The Yellow Llama | Web Design South Africa, Port Elizabeth Web Design, Search Engine Optimization

Epic FAIL’s from around the world | The Yellow Llama | Web Design South Africa, Port Elizabeth Web Design, Search Engine Optimization

Epic FAIL’s from around the world | The Yellow Llama | Web Design South Africa, Port Elizabeth Web Design, Search Engine Optimization

Epic FAIL’s from around the world | The Yellow Llama | Web Design South Africa, Port Elizabeth Web Design, Search Engine Optimization

Epic FAIL’s from around the world | The Yellow Llama | Web Design South Africa, Port Elizabeth Web Design, Search Engine Optimization

Epic FAIL’s from around the world | The Yellow Llama | Web Design South Africa, Port Elizabeth Web Design, Search Engine Optimization

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3s18-pakistan_jpg_j_772747a.jpg (JPEG Image, 440x297 pixels)

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sun-and-love.jpg (JPEG Image, 504x447 pixels)

50 Amazing Digital Painting Portraits | Abduzeedo - design inspiration and tutorials

50 Amazing Digital Painting Portraits | Abduzeedo - design inspiration and tutorials

50 Amazing Digital Painting Portraits | Abduzeedo - design inspiration and tutorials

50 Amazing Digital Painting Portraits | Abduzeedo - design inspiration and tutorials

50 Amazing Digital Painting Portraits | Abduzeedo - design inspiration and tutorials

50 Amazing Digital Painting Portraits | Abduzeedo - design inspiration and tutorials

50 Amazing Digital Painting Portraits | Abduzeedo - design inspiration and tutorials

50 Amazing Digital Painting Portraits | Abduzeedo - design inspiration and tutorials

50 Amazing Digital Painting Portraits | Abduzeedo - design inspiration and tutorials

50 Amazing Digital Painting Portraits | Abduzeedo - design inspiration and tutorials

word,art,information,graphics,type:photography,type:words,beings,black,and,white-51df0e1bdf8a52d6c8e12f3c2b6b744c_h.jpg (JPEG Image, 500x332 pixels)

word,art,information,graphics,type:photography,type:words,beings,black,and,white-51df0e1bdf8a52d6c8e12f3c2b6b744c_h.jpg (JPEG Image, 500x332 pixels)

itsonlythewind - Someday, someone is going to walk into your life...

“ Someday, someone is going to walk into your life and make you realize why it never worked out with anyone else.

itsonlythewind - Someday, someone is going to walk into your life...

Bipolar Disorder: What Is It - Bipolar Disorder Center - EverydayHealth.com

Bipolar disorder, which used to be called manic depressive illness or manic depression, is a mental disorder characterized by wide mood swings from high (manic) to low (depressed).

Periods of high or irritable moods are called "manic" episodes. The person becomes very active, but in a scattered and unproductive way, sometimes with painful or embarrassing consequences. Examples are spending more money than is wise or getting involved in sexual adventures that are regretted later. A person in a manic state is full of energy or very irritable, may sleep far less than normal, and may dream up grand plans that could never be carried out. The person may develop thinking that is out of step with reality — psychotic symptoms — such as false beliefs (delusions) or false perceptions (hallucinations). During manic periods, a person may run into trouble with the law. If a person has milder symptoms of mania and does not have psychotic symptoms, it is called a "hypomanic" episode.

Bipolar disorder is now divided into two subtypes (bipolar I and bipolar II). Bipolar I disorder is the classic form where a person has had at least one manic episode. In bipolar II disorder, the person has never had a manic episode, but has had at least one hypomanic episode and at least one period of severe depression. Bipolar II disorder may be more common than bipolar I. A third disorder, closely related to bipolar disorder, is cyclothymia — people with this disorder fluctuate between hypomania and mild or moderate depression.

The vast majority of people who have manic episodes also experience periods of depression. If manic and depressive symptoms overlap for a period, it is called a "mixed" episode. In some people, moods alternate rapidly or it is difficult to tell which mood — depression or mania — is more prominent.

People who have one manic episode most likely will have others if they do not seek treatment. The illness tends to run in families. Unlike depression, in which women are more frequently diagnosed, bipolar disorder happens nearly equally in men and women. Bipolar I and II disorders occur in up to 4% of the population.

The most important risk of this illness is the risk of suicide. People who have bipolar disorder are also more likely to abuse alcohol or other substances.

Bipolar Disorder: What Is It - Bipolar Disorder Center - EverydayHealth.com

Bacon Explosion: The BBQ Sausage Recipe of all Recipes

Bacon Explosion: The BBQ Sausage Recipe of all Recipes

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joejet.com_000125-11_ssorted-images.jpg (JPEG Image, 750x516 pixels)

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picture_16.png (PNG Image, 410x394 pixels)

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039_16030~Natalie-Portman-Posters.jpg (JPEG Image, 337x425 pixels)

1233043000553.jpg (JPEG Image, 1000x779 pixels) - Scaled (65%)

1233043000553.jpg (JPEG Image, 1000x779 pixels) - Scaled (65%)

Strangemall.com » Pizza Clippers

Strangemall.com » Pizza Clippers

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2312298250_d6a3626ab4.jpg (JPEG Image, 500x500 pixels)

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20090109112737.jpg (JPEG Image, 500x375 pixels)

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chrissie_white_04.jpg (JPEG Image, 500x499 pixels)

The most effective debt collecting email I ever wrote | For A Beautiful Web

The most effective debt collecting email I ever wrote

Running a small business means that I divide my time between the things that I love doing (project planning, designing and dealing with people) and the things that I don't enjoy so much (business planning, accounting and dealing with (some) people).

Along the way, one of the facets of business that I've had to learn is how to handle those very rare occasions when people seem reluctant to pay promptly. Oddly late payers are rarely those who owe thousands, but instead owe very little for tasks that take only a few short minutes or hours to complete.

If you're unlucky, what at first might seem like a slice of bread and butter, can become a long and drawn-out series of repeat invoices and statements, phone calls, emails or reminder letters. You might, in the end, spend more time chasing payment than you spent on the task. With every email or phone call that goes by, your profit diminishes.

To me, late payment is rarely an issue about money and more about a lack of respect. This is particularly true if you are unfortunate to work with people who expect you to respond quickly to service their needs, but don't apply the same standards to yours.

Several weeks ago, my debtors sheet listed three customers with invoices that were outstanding over sixty and, in one case, ninety days. I thought about how best to handle this potentially awkward situation? Should I stick to the conventional path of statements and reminders that would drain my time and energy and divert my attention?

I chose to abandon a stiff business approach and instead write one email, carefully worded to express how I personally felt. After-all, business may be business, but people work with people.

The most effective debt collecting email I ever wrote | For A Beautiful Web

Loch Abar on a Cold Morning | Bill Lockhart Photography

Loch Abar on a Cold Morning | Bill Lockhart Photography

THC cuts lung cancer growth, spread | Science Blog

The active ingredient in marijuana cuts tumor growth in common lung cancer in half and significantly reduces the ability of the cancer to spread, say researchers at Harvard University who tested the chemical in both lab and mouse studies.

They say this is the first set of experiments to show that the compound, Delta-tetrahydrocannabinol (THC), inhibits EGF-induced growth and migration in epidermal growth factor receptor (EGFR) expressing non-small cell lung cancer cell lines. Lung cancers that over-express EGFR are usually highly aggressive and resistant to chemotherapy.

THC that targets cannabinoid receptors CB1 and CB2 is similar in function to endocannabinoids, which are cannabinoids that are naturally produced in the body and activate these receptors. The researchers suggest that THC or other designer agents that activate these receptors might be used in a targeted fashion to treat lung cancer.

"The beauty of this study is that we are showing that a substance of abuse, if used prudently, may offer a new road to therapy against lung cancer," said Anju Preet, Ph.D., a researcher in the Division of Experimental Medicine.

Acting through cannabinoid receptors CB1 and CB2, endocannabinoids (as well as THC) are thought to play a role in variety of biological functions, including pain and anxiety control, and inflammation. Although a medical derivative of THC, known as Marinol, has been approved for use as an appetite stimulant for cancer patients, and a small number of U.S. states allow use of medical marijuana to treat the same side effect, few studies have shown that THC might have anti-tumor activity, Preet says. The only clinical trial testing THC as a treatment against cancer growth was a recently completed British pilot study in human glioblastoma.

In the present study, the researchers first demonstrated that two different lung cancer cell lines as well as patient lung tumor samples express CB1 and CB2, and that non-toxic doses of THC inhibited growth and spread in the cell lines. "When the cells are pretreated with THC, they have less EGFR stimulated invasion as measured by various in-vitro assays," Preet said.

Then, for three weeks, researchers injected standard doses of THC into mice that had been implanted with human lung cancer cells, and found that tumors were reduced in size and weight by about 50 percent in treated animals compared to a control group. There was also about a 60 percent reduction in cancer lesions on the lungs in these mice as well as a significant reduction in protein markers associated with cancer progression, Preet says.

Although the researchers do not know why THC inhibits tumor growth, they say the substance could be activating molecules that arrest the cell cycle. They speculate that THC may also interfere with angiogenesis and vascularization, which promotes cancer growth.

Preet says much work is needed to clarify the pathway by which THC functions, and cautions that some animal studies have shown that THC can stimulate some cancers. "THC offers some promise, but we have a long way to go before we know what its potential is," she said.

Staci Vernick Goldberg
goldberg@aacr.org
267-646-0616

THC cuts lung cancer growth, spread | Science Blog

Ecstasy 'no more dangerous than horse riding' - Telegraph

A handful of different types of Ecstasy pills Photo: PA

Writing in an academic journal, Professor David Nutt said taking ecstasy was no worse than the risks of "equasy", a term he invented to describe people's addiction to horse-riding.

Prof Nutt is the chairman of the Home Office's Advisory Council on the Misuse of Drugs which next week is likely to say that ecstasy should be downgraded to a Class B drug.

Campaigners last night called for him to resign, suggesting that he was on a "personal crusade" to decriminalise the drug.

Prof Nutt, who is an academic at Bristol University and Imperial College, London, wrote the article in the Journal of Psychopharmacology last month.

He said he wanted to compare the risks of horse-riding with the drug to open a debate about drug abuse and risk taking.

Prof Nutt told The Daily Telegraph: "The point was to get people to understand that drug harm can be equal to harms in other parts of life.

"There is not much difference between horse riding and ecstasy."

In the article, titled "Equasy: An overlooked addiction with implications for the current debate on drug harms", Prof Nutt wrote that "equasy", short for "Equine Addiction Syndrome", had caused 10 deaths and more than 100 road traffic accidents a year.

Through hunting, it also led to "gatherings of users that often are associated with these groups engaging in violent conduct.

"Dependence, as defined by the need to continue to use, has been accepted by the courts in divorce settlements," he wrote. "Based on these harms, it seems likely that the ACMD would recommend control under the MDAct perhaps as a class A drug given it appears more harmful than ecstasy."

He wrote that the risks of horse riding showed that society "does not adequately balance the relative risks of drugs against their harms".

He said: "Making riding illegal would completely prevent all these harms and would be, in practice, very easy to do.

"This attitude raises the critical question of why society tolerates – indeed encourages – certain forms of potentially harmful behaviour but not others, such as drug use."

There were plenty of other "risky activities such as base jumping, climbing, bungee jumping, hang-gliding, motorcycling" which were worse than which "many illicit drugs".

Campaigners said Prof Nutt's comments were ill-judged, coming ahead of the council on whether to downgrade the drug from A to B.

David Raynes, an executive councillor at the National Drug Prevention Alliance said: "Professor Nutt has made numerous unwise comments prejudging the ACMD review of Ecstasy. Is he on a personal crusade against the laws enacted by Parliament?

"He is entitled to his opinion, but if his personal view conflicts so very strongly with his public duties, it would be honourable to consider his position.

"If he does not, the Home Secretary should certainly do it for him."

The advisory council insisted that Prof Nutt was writing in the journal "in respect of his academic work and not as chair of the ACMD".

A spokesman said: "Prof Nutt's academic research does not prejudice the work that he conducts as chair of the ACMD."

There are 500,000 regular users and between 30 million and 60 million ecstasy pills in circulation in the UK.

If the advisory council recommends downgrading ecstasy next week, the Government can over-rule it - as happened with cannabis this year.

The council heard last year that deaths among ecstasy users had trebled from 10 to 30 a year over the past 15 years. The cost of pills had slumped from £15.50 to £2.30.

Ecstasy 'no more dangerous than horse riding' - Telegraph

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snow.jpg (JPEG Image, 700x529 pixels)